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The role of the microbiome in regulating bone remodeling was shown in germ free mice (in C57BL/6 background) which have increased femoral bone density (both trabecular and cortical) when compared to conventionally raised mice [132]

Even if a fraction of the active ingredient reaches the small intestine intact, its absorption is often severely restricted due to unfavorable molecular size, poor intestinal permeability, and extensive hepatic first-pass metabolism

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Am J Med (1989) 87(3):295300